Research Shows Potential Impact of Betaine on Fat Metabolism

Betafin®, part of the DuPont™ Danisco® portfolio, has significant effects on adipose tissue metabolism and inflammation in a diet induced obesity model

KANTVIK, Finland, Dec. 19, 2018 – For more than two decades, DuPont scientists have been at the forefront of studying the physiological effects of betaine and developing products that relieve metabolic stress situations in the body, including those caused by consumption of a high-fat diet. Betaine, a N-trimethylated amino acid, is produced in various plant species as a response to e.g., environmental stresses such as dehydration. It functions as an essential nutrient for methylation, a key process in metabolism, and is one of the most powerful organic osmolytes found in living organisms (helping cells to adapt to osmotic stresses such as dehydration or fluid excess).

Continuing its leading research work in conjunction with the University of Eastern Finland, DuPont Nutrition & Health (DuPont) released the findings of a research study showing that natural Betafin® betaine, part of the DuPont™ Danisco® portfolio, enhanced the metabolism in fat (adipose) tissue and reduced inflammation in mice being fed a high fat “Western diet.” The favorable metabolic changes brought about by betaine feeding included increasing fat tissue carnitine which may prevent lipid accumulation in fat tissues, and therefore offers potential benefits in reducing obesity.

“Our previous in vitro adipose tissue experiments indicated that betaine reduces inflammation caused by hypoxia and in the current study we were able to see the same response in the in vivo obesity model,” said Senior Scientist Kaisa Airaksinen, DuPont Nutrition & Health.

“This study exemplifies DuPont’s commitment to long-term science behind our products,” said Kirsti Tiihonen, Ph.D., DuPont Nutrition & Health. “Betaine is an example of the research we’ve been performing in Kantvik, Finland, for more than 20 years using our own preclinical modelling expertise and the collaboration with external partners in the areas of omics techniques as well as clinical trials.”

Among the study’s other achievements was the comparison of adipose tissue gene expression and nontargeted metabolite profiles. “While this study was conducted on animals, the metabolic effects are presumably in line with what could be seen in humans,” said Kati Hanhineva, Ph.D., University of Eastern Finland. “These kinds of study approaches can give more understanding on the metabolic mode of action of products, and how they can impact the health of human body.”

You can read more about this research study at https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201800455.

About DuPont Nutrition & Health

DuPont Nutrition & Health, a DowDuPont Specialty Products Division business, combines in-depth knowledge of food and nutrition with current research and expert science to deliver unmatched value to the food, beverage, pharmaceutical and dietary supplement industries. We are innovative solvers, drawing on deep consumer insights and a broad product portfolio to help our customers turn challenges into high-value business opportunities. More information is available at www.food.dupont.com.

About DowDuPont Specialty Products Division

DowDuPont Specialty Products, a division of DowDuPont (NYSE: DWDP), is a global innovation leader with technology-based materials, ingredients and solutions that help transform industries and everyday life. Our employees apply diverse science and expertise to help customers advance their best ideas and deliver essential innovations in key markets including electronics, transportation, building and construction, health and wellness, food and worker safety. DowDuPont intends to separate the Specialty Products Division, which will be called DuPont, into an independent, publicly traded company. More information can be found at www.dow-dupont.com.

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